CovidV1, Main, Exploration, bibRecord, 000A28

Inhaled anti-infective chemotherapy for respiratory tract infections: Successes, challenges and the road ahead

Identifieur interne : 000A28 ( Main/Exploration ); précédent : 000A27; suivant : 000A29

Inhaled anti-infective chemotherapy for respiratory tract infections: Successes, challenges and the road ahead

Auteurs : Tony Velkov [Australie] ; Nusaibah Abdul Rahim [Australie] ; Qi Tony Zhou [Australie] ; Hak-Kim Chan [Australie] ; Jian Li [Australie]

Source :

Advanced drug delivery reviews [ 0169-409X ] ; 2014.

RBID : PMC:4429008

Abstract

One of the most common causes of illnesses in humans is from respiratory tract infections caused by bacterial, viral or fungal pathogens. Inhaled anti-infective drugs are crucial for the prophylaxis and treatment of respiratory tract infections. The benefit of anti-infective drug delivery via inhalation is that it affords delivery of sufficient therapeutic dosages directly to the primary site of infection, while minimizing the risks of systemic toxicity or avoiding potential suboptimal pharmacokinetics/pharmacodynamics associated with systemic drug exposure. This review provides an up-to-date treatise of approved and novel developmental inhaled anti-infective agents, with particular attention to effective strategies for their use, pulmonary pharmacokinetic properties and safety.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429008

DOI: 10.1016/j.addr.2014.11.004
PubMed: 25446140
PubMed Central: 4429008

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p id="P2">One of the most common causes of illnesses in humans is from respiratory tract infections caused by bacterial, viral or fungal pathogens. Inhaled anti-infective drugs are crucial for the prophylaxis and treatment of respiratory tract infections. The benefit of anti-infective drug delivery via inhalation is that it affords delivery of sufficient therapeutic dosages directly to the primary site of infection, while minimizing the risks of systemic toxicity or avoiding potential suboptimal pharmacokinetics/pharmacodynamics associated with systemic drug exposure. This review provides an up-to-date treatise of approved and novel developmental inhaled anti-infective agents, with particular attention to effective strategies for their use, pulmonary pharmacokinetic properties and safety.</p>
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Inhaled anti-infective chemotherapy for respiratory tract infections: Successes, challenges and the road ahead

Inhaled anti-infective chemotherapy for respiratory tract infections: Successes, challenges and the road ahead

Source :

Abstract

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